N-BENZYL-4-FLUOROPHENYLGLYCINE

Base Information

• Chemical Name: N-BENZYL-4-FLUOROPHENYLGLYCINE
• CAS No.: 200000-54-0
• Molecular Formula: C15H14 F N O2
• Molecular Weight: 259.28
• Hs Code.: 2922499990
• Mol file: 200000-54-0.mol

Synonyms:4-Fluoro-alpha-[(Phenylmethyl)Amino]-Benzeneacetic Acid;

Chemical Property of N-BENZYL-4-FLUOROPHENYLGLYCINE

Chemical Property:

• Boiling Point: 391.9±37.0 °C(Predicted)
• PKA: 1.76±0.10(Predicted)
• PSA: 49.33000
• Density: 1.247±0.06 g/cm3(Predicted)
• LogP: 3.13210
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Benzylamino)-2-(4-fluorophenyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BENZYL-4-FLUOROPHENYLGLYCINE

There total 8 articles about N-BENZYL-4-FLUOROPHENYLGLYCINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(N-benzyl)amino-2-(4-fluorophenyl)acetamide (271583-38-1) → N-benzyl-4-fluorophenylglycine (200000-54-0,159707-18-3)

Guidance literature:

With sodium hydroxide; water; In various solvent(s); for 3.5h; Heating;

DOI:10.1080/00397910008087127

Reference yield:

sodium metabisulfite + aqueous sodium chloride + 4-fluorobenzaldehyde (459-57-4) + benzylamine (100-46-9) → N-benzyl-4-fluorophenylglycine (200000-54-0,159707-18-3)

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; potassium carbonate; In methanol; water; dimethyl sulfoxide;

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + C14H12FNO (1018683-57-2,1165676-44-7) → N-benzyl-1-(4-fluorophenyl)methanamine (55096-88-3) + N-benzyl-4-fluorophenylglycine (200000-54-0,159707-18-3) + N,N-dibenzyl-1,2-bis(4-fluorophenyl)ethane-1,2-diamine + N,N-dibenzyl-1,2-bis(4-fluorophenyl)ethane-1,2-diamine

Guidance literature:

carbon dioxide; C₁₄H₁₂FNO; With samarium diiodide; In tetrahydrofuran; at 20 ℃; for 16h; under 37503.8 Torr; Autoclave;

With trifluoroacetic acid; In tetrahydrofuran; water;

DOI:10.1002/ejoc.201200440

upstream raw materials:

2-(N-benzyl)amino-2-(4-fluorophenyl)acetamide

[(diphenylmethyl)amino](4-fluorophenyl)acetonitrile

4-fluorobenzaldehyde

benzylamine

Downstream raw materials:

4-benzyl-3-(4-fluorophenyl)morpholin-2-one

(2RS)-N-(p-fluorophenyl)glycine

3-(S)-(4-Fluorophenyl)-4-benzyl-2-morpholinone

Refernces

• 1、 Davies, Antony J.,Ashwood, Michael S.,Cottrell, Ian F.. "A facile synthesis of substituted phenylglycines". . p. 1095 - 1102. Retrieved 2007/10/03.
• 2、 -. "MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS". . . Retrieved 2008/06/13.