2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID

Base Information

• Chemical Name: 2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID
• CAS No.: 87184-23-4
• Molecular Formula: C14H18 F N O4
• Molecular Weight: 283.29500
• Mol file: 87184-23-4.mol

Synonyms:DL-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-3-fluoro-

Chemical Property of 2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID

Chemical Property:

• PSA: 75.63000
• LogP: 2.73700

Purity/Quality:

99% ^*data from raw suppliers

2-((tert-Butoxycarbonyl)amino)-3-(3-fluorophenyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID

There total 2 articles about 2-[(TERT-BUTOXYCARBONYL)AMINO]-3-(3-FLUOROPHENYL)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile (58632-95-4) + 3-fluorophenylalanine (456-88-2,2629-54-1) → Boc-DL-m-FPhe (87184-23-4,114873-11-9)

Guidance literature:

With triethylamine; In 1,4-dioxane; water; for 2.5h;

DOI:10.1021/jm00366a013

Reference yield:

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + di-tert-butyl dicarbonate (24424-99-5) + 3-fluorophenylalanine (456-88-2,2629-54-1) → Boc-DL-m-FPhe (87184-23-4,114873-11-9)

Guidance literature:

With sodium carbonate; In water;

Reference yield: 89.0%

2-bromo-6-(4-pyridin-2-yl-piperazin-1-yl)-indeno[2,1-c]quinolin-7-one oxime (1173289-99-0) + Boc-DL-m-FPhe (87184-23-4,114873-11-9) → tert-butyl 1-(2-bromo-6-(4-(pyridin-2-yl)piperazin-1-yl)-7H-indeno[2,1-c]quinolin-7-ylideneaminooxy)-3-(3-fluorophenyl)-1-oxopropan-2-ylcarbamate (1293989-63-5)

Guidance literature:

2-bromo-6-(4-pyridin-2-yl-piperazin-1-yl)-indeno[2,1-c]quinolin-7-one oxime; With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

Boc-DL-m-FPhe; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.01.053

upstream raw materials:

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

3-fluorophenylalanine

1,4-dioxane

di-tert-butyl dicarbonate

Downstream raw materials:

Boc-DL-m-FPhe-OSu

Boc-DL-m-FPhe-L-Ala-L-Ala

Boc-DL-m-FPhe-L-Met-L-Met

D-m-FPhe-L-Ala-L-Ala