N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole

Base Information

• Chemical Name: N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole
• CAS No.: 124417-92-1
• Molecular Formula: C₂₉H₂₂N₂O₃
• Molecular Weight: 446.505
• Mol file: 124417-92-1.mol

Synonyms:N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole

Chemical Property of N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole

There total 2 articles about N⁵,1-Dibenzoyl-5-amino-7-benzyloxyindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1,N4-Dibenzoyl-2-(benzyloxy)-p-benzoquinone Diimine (114996-60-0) → N5,1-Dibenzoyl-5-amino-7-benzyloxyindole (124417-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 25 °C

2: 1) OsO₄, NaIO₄, 2) H₂SO₄ (5percent in CH₂Cl₂) / 1) acetone, water, 25 deg C, 2) CH₂Cl₂, 25 deg C

With sodium periodate; osmium(VIII) oxide; sulfuric acid; boron trifluoride diethyl etherate; In dichloromethane;

DOI:10.1021/jo00291a059

Reference yield:

O-Benzyl-N2,N5-dibenzoyl-2,5-diamino-3-<3-(1-propenyl)>phenol (124400-64-2) → N5,1-Dibenzoyl-5-amino-7-benzyloxyindole (124417-92-1)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; sulfuric acid; Yield given. Multistep reaction; 1) acetone, water, 25 deg C, 2) CH₂Cl₂, 25 deg C;

DOI:10.1021/jo00291a059

Reference yield: 45.0%

N5,1-Dibenzoyl-5-amino-7-benzyloxyindole (124417-92-1) → 1-benzoyl-5-(benzoylamino)-7-(benzyloxy)-4-iodoindole (227084-81-3)

Guidance literature:

With N-iodo-succinimide; toluene-4-sulfonic acid; In tetrahydrofuran; at 25 ℃; for 40h;

DOI:10.1021/jo000297j

upstream raw materials:

O-Benzyl-N²,N⁵-dibenzoyl-2,5-diamino-3-<3-(1-propenyl)>phenol

N¹,N⁴-Dibenzoyl-2-(benzyloxy)-p-benzoquinone Diimine

Downstream raw materials:

1-benzoyl-5-(benzoylamino)-7-(benzyloxy)-4-iodoindole

5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3-[(1H-indol-2-yl)carbonyl]-3H-pyrrolo[3,2-e]indole

5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3-[(5-methoxy-1H-indol-2-yl)carbonyl]-3H-pyrrolo[3,2-e]indole

5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3H-pyrrolo[3,2-e]indole