t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

Base Information

• Chemical Name: t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate
• CAS No.: 480450-94-0
• Molecular Formula: C₂₃H₃₀ClFN₄O₄
• Molecular Weight: 480.967

Synonyms:t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

Chemical Property of t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

Chemical Property:

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Technology Process of t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate

There total 1 articles about t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(1S,2R,4S)-N2-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine (365998-36-3) + 5-chloro-3-fluoroindole-2-carboxylic acid (480450-93-9) → t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate (480450-94-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2009.10.023

Reference yield:

t-butyl {(1R,2S,5S)-2-{[(5-chloro-3-fluoroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate (480450-94-0) → C18H22ClFN4O2 (1295297-92-5)

Guidance literature:

With hydrogenchloride; In ethanol; dichloromethane;

DOI:10.1016/j.bmc.2009.10.023

upstream raw materials:

(1S,2R,4S)-N₂-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine

5-chloro-3-fluoroindole-2-carboxylic acid

Downstream raw materials:

C₁₈H₂₂ClFN₄O₂

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