[(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester
• CAS No.: 746637-72-9
• Molecular Formula: C₂₆H₂₇N₃O₄
• Molecular Weight: 445.518
• Mol file: 746637-72-9.mol

Synonyms:[(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester

Chemical Property of [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester

There total 4 articles about [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

D-α-methyl-α-phenylglycinamide (152375-69-4) + C34H32N2O7 (746637-65-0) → [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester (746637-72-9)

Guidance literature:

With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 144h;

DOI:10.1016/j.tetasy.2004.04.044

Reference yield:

(R)-2-amino-2-phenylpropanoic acid (29738-09-8,6945-32-0) → [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester (746637-72-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / NaOH; NaHCO₃ / dioxane / 384 h / 20 °C

2: 94 percent / N-ethyl,N'-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

3: 81 percent / acetonitrile / 20 °C

4: 52 percent / NMM / CH₂Cl₂ / 144 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; acetonitrile;

DOI:10.1016/j.tetasy.2004.04.044

Reference yield:

(R)-N2-<(benzyloxy)carbonyl>-2-methyl-2-phenylglycine (746637-52-5) → [(R)-1-((R)-1-Carbamoyl-1-phenyl-ethylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester (746637-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / N-ethyl,N'-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂ / 2 h / 20 °C

2: 81 percent / acetonitrile / 20 °C

3: 52 percent / NMM / CH₂Cl₂ / 144 h / 20 °C

With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetasy.2004.04.044

upstream raw materials:

D-α-methyl-α-phenylglycinamide

C₃₄H₃₂N₂O₇

(R)-2-amino-2-phenylpropanoic acid

(R)-N²-<(benzyloxy)carbonyl>-2-methyl-2-phenylglycine