2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

• Chemical Name: 2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester
• CAS No.: 86136-93-8
• Molecular Formula: C₁₇H₂₃NO₄
• Molecular Weight: 305.374
• Mol file: 86136-93-8.mol

Synonyms:2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property of 2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester

There total 1 articles about 2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pent-4-enylcarbamic acid benzyl ester (86136-88-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester (86136-93-8)

Guidance literature:

With mercury(II) diacetate; sodium trimethoxyborohydride; Yield given. Multistep reaction; 2.) dichloromethane;

DOI:10.1016/S0040-4039(00)81313-1

Reference yield:

2-(3-Methoxycarbonyl-propyl)-pyrrolidine-1-carboxylic acid benzyl ester (86136-93-8) → indolizidine (13618-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / hydrogenolysis

2: LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)81313-1

upstream raw materials:

pent-4-enylcarbamic acid benzyl ester

acrylic acid methyl ester

Downstream raw materials:

indolizidine