methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

Base Information

Chemical Name:methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate
CAS No.:148838-45-3
Molecular Formula:C₂₂H₂₉NO₅S
Molecular Weight:419.542
Hs Code.:

Synonyms:methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

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Technology Process of methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

There total 6 articles about methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186800-92-0
(1R,2Z,4S)-N-<4-<(2-methoxyethoxy)methoxy>-1-phenyl-2-pentenyl>-2,4,6-trimethylbenzenesulfonamide

: 148838-45-3
methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -30 deg C, 2.) -60 deg C to r.t., 2 h

2: TiCl₄ / CH₂Cl₂ / 1.) -78 to -40 deg C, 30 min, 2.) -78 to -40 deg C, 1 h

With dimethylsulfide; titanium tetrachloride; ozone; In dichloromethane;
DOI:10.1002/jlac.199719970121

Reference yield:

: 148838-33-9
(1S,2E,4S)-N-<2-bromo-4-<(2-methoxyethoxy)methoxy>-1-phenyl-2-pentenyl>-2,4,6-trimethylbenzenesulfonamide

: 148838-45-3
methyl (3S,4S)-3-hydroxy-2,2-dimethyl-4-phenyl-4-<<(2,4,6-trimethylphenyl)sulfonyl>amino>butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / tert-BuLi, aq. NH₄Cl / 1.) THF, pentane, -95 to -30 deg C, 1 h, 2.) MeOH

2: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, -30 deg C, 2.) -60 deg C to r.t., 2 h

3: TiCl₄ / CH₂Cl₂ / 1.) -78 to -40 deg C, 30 min, 2.) -78 to -40 deg C, 1 h

With dimethylsulfide; tert.-butyl lithium; titanium tetrachloride; ammonium chloride; ozone; In dichloromethane;
DOI:10.1002/jlac.199719970121