4-AMINO-2-SULFOBENZOIC ACID

Base Information

• Chemical Name: 4-AMINO-2-SULFOBENZOIC ACID
• CAS No.: 527-76-4
• Molecular Formula: C7H7 N O5 S
• Molecular Weight: 217.202
• Hs Code.: 2922499990
• Mol file: 527-76-4.mol

Synonyms:4-Amino-2-sulfobenzoicacid; p-Amino-o-sulfobenzoic acid

Chemical Property of 4-AMINO-2-SULFOBENZOIC ACID

Chemical Property:

• PSA: 126.07000
• Density: 1.71g/cm³
• LogP: 1.87570

Purity/Quality:

99%, ^*data from raw suppliers

4-Amino-2-sulfobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-2-SULFOBENZOIC ACID

There total 6 articles about 4-AMINO-2-SULFOBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-carboxy-5-nitrobenzenesulfonic acid (22952-26-7) → 4-amino-2-sulfobenzoic acid (527-76-4)

Guidance literature:

With iron; acetic acid; In water; for 1.16667h; Reflux;

Reference yield:

water (7732-18-5) + potassium cyanide (151-50-8) + nitrobenzene 3-sulfonic acid potassium salt (4346-48-9) → 4-sulfoanthranilic acid (98-43-1) + 4-amino-2-sulfobenzoic acid (527-76-4) + 2-amino-6-sulfo-benzoic acid (25352-27-6)

Guidance literature:

Reference yield:

4-nitrotoluene-2-sulfonic acid (121-03-9) → 4-amino-2-sulfobenzoic acid (527-76-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium permanganate / water / 5 h / 115 °C

2: iron; acetic acid / water / 1.17 h / Reflux

With potassium permanganate; iron; acetic acid; In water;

upstream raw materials:

2-carboxy-5-nitrobenzenesulfonic acid

potassium cyanide

water

nitrobenzene 3-sulfonic acid potassium salt

Refernces

• 1、 -. "ALBUMIN-BINDING PRODRUGS OF AURISTATIN E DERIVATIVES". Paragraph 00164. . Retrieved 2019/06/17.