(R)-3-benzyloxycarbonyl-2-pentylpropanoic acid

Base Information

• Chemical Name: (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid
• CAS No.: 611212-55-6
• Molecular Formula: C₁₆H₂₂O₄
• Molecular Weight: 278.348
• Mol file: 611212-55-6.mol

Synonyms:(R)-3-benzyloxycarbonyl-2-pentylpropanoic acid

Chemical Property of (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid

There total 1 articles about (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl 4-[(S)-4-benzyl-2-oxooxazolidin-3-yl]-3-pentyl-4-oxobutanoate (1035609-58-5) → (R)-3-benzyloxycarbonyl-2-pentylpropanoic acid (611212-55-6)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmc.2008.02.024

Reference yield: 100.0%

(R)-3-benzyloxycarbonyl-2-pentylpropanoic acid (611212-55-6) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-phenylalanine methyl ester (1035610-05-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.02.024

Reference yield: 100.0%

(R)-3-benzyloxycarbonyl-2-pentylpropanoic acid (611212-55-6) + L-tert-leucine methyl ester hydrochloride (63038-27-7,167223-43-0) → N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-tert-leucine methyl ester (1035610-03-7)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.02.024

upstream raw materials:

benzyl 4-[(S)-4-benzyl-2-oxooxazolidin-3-yl]-3-pentyl-4-oxobutanoate

Downstream raw materials:

N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]glycine methyl ester

N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-alanine methyl ester

N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-valine methyl ester

N-[(R)-3-benzyloxycarbonyl-2-pentylpropanoyl]-L-leucine methyl ester