N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

Base Information

Chemical Name:N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide
CAS No.:852660-60-7
Molecular Formula:C₂₉H₃₉FN₄O₃
Molecular Weight:510.652
Hs Code.:

Synonyms:N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

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Chemical Property of N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

Chemical Property:

Purity/Quality:

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Hazard Codes:

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Technology Process of N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

There total 23 articles about N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 405905-06-8
phenyl (3-acetylphenyl)carbamate

: 852660-67-4
C₂₀H₃₂FN₃O

: 852660-60-7
N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

: 852660-61-8
N-((1S,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852660-60-7
N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

: 852660-61-8
N-((1S,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: borane-THF / tetrahydrofuran / 25 °C / Heating / reflux

3.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

4.1: tetrahydrofuran / 25 °C

5.1: dichloromethane / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride / water; acetonitrile / 24 h / 20 °C

7.1: ethanol / 0.5 h

7.2: 72 h / 20 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

10.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; sodium hydroxide; borane-THF; water; hydrogen; phosphorus tribromide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852660-60-7
N-((1R,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[3-(4-fluorophenyl)propyl(methyl)amino]methyl}cyclohexyl)-N-methylacetamide

: 852660-61-8
N-((1S,3R,4S)-3-({[(3-acetylphenyl)amino]carbonyl}amino)-4{[[3-(4-fluorophenyl)propyl](methyl)amino]methyl}cyclohexyl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

2.2: 1 h

3.1: phosphorus tribromide / chloroform / 25 °C / Heating / reflux

4.1: tetrahydrofuran / 25 °C

5.1: dichloromethane / 0.5 h / 20 °C

5.2: 16 h / 20 °C

6.1: hydrogenchloride / water; acetonitrile / 24 h / 20 °C

7.1: ethanol / 0.5 h

7.2: 72 h / 20 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

9.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 760.05 Torr

10.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetonitrile;