BOC-D-GLU(OFM)-OH

Base Information

• Chemical Name: BOC-D-GLU(OFM)-OH
• CAS No.: 123417-20-9
• Molecular Formula: C₂₄H₂₇NO₆
• Molecular Weight: 425.481
• Mol file: 123417-20-9.mol

Synonyms:N-ALPHA-T-BUTOXYCARBONYL-D-GLUTAMIC ACID GAMMA-9-FLUORENYL METHYL ESTER;BOC-D-GLU(OFM)-OH;BOC-D-GLUTAMIC ACID GAMMA-9-FLUORENYLMETHYL ESTER;BOC-D-GLUTAMIC ACID(OFM)-OH

Chemical Property of BOC-D-GLU(OFM)-OH

Chemical Property:

• Melting Point: 129.5-130.5 °C
• Boiling Point: 633.5±55.0 °C(Predicted)
• PKA: 3.80±0.10(Predicted)
• PSA: 101.93000
• Density: 1.232±0.06 g/cm3(Predicted)
• LogP: 4.49110
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Boc-D-glutamic acid γ-9-fluorenylmethyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-GLU(OFM)-OH

There total 5 articles about BOC-D-GLU(OFM)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

di-tert-butyl dicarbonate (24424-99-5) + L-glutamic acid γ-9-fluorenylmethyl ester (141215-68-1) → N-Boc-L-glutamic acid δ-fluorenylmethyl ester (123417-18-5,123417-20-9)

Guidance literature:

In 1,4-dioxane; water;

DOI:10.1080/00397919208019289

Reference yield: 80.0%

di-tert-butyl dicarbonate (24424-99-5) + L-glutamic acid δ-fluorenylmethyl ester hydrochloride (129046-85-1) → N-Boc-L-glutamic acid δ-fluorenylmethyl ester (123417-18-5,123417-20-9)

Guidance literature:

L-glutamic acid δ-fluorenylmethyl ester hydrochloride; With sodium carbonate;

di-tert-butyl dicarbonate;

DOI:10.1021/jo901218g

Reference yield: 79.0%

{[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile (80994-44-1) + L-glutamic acid δ-fluorenylmethyl ester hydrochloride (129046-85-1) → N-Boc-L-glutamic acid δ-fluorenylmethyl ester (123417-18-5,123417-20-9)

Guidance literature:

With sodium carbonate; In tetrahydrofuran; water; 1) 0 deg C, 15 min (pH 9.5) 2) 25 deg C, 2 h;

DOI:10.1055/s-1990-26804

upstream raw materials:

di-tert-butyl dicarbonate

L-glutamic acid γ-9-fluorenylmethyl ester

{[(tert-butoxycarbonyl)oxy]amino}(phenyl)acetonitrile

L-glutamic acid δ-fluorenylmethyl ester hydrochloride

Refernces

• 1、 Belshaw,Adamson,Lajoie. "Single step syntheses of ω-9-fluorenylmethyl esters of aspartic and glutamic acids". . p. 1001 - 1005. Retrieved 2007/10/02.