N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester

Base Information

• Chemical Name: N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester
• CAS No.: 87010-64-8
• Molecular Formula: C₁₄H₂₂NO₅P
• Molecular Weight: 315.306
• Mol file: 87010-64-8.mol

Synonyms:N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester

Chemical Property of N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester

There total 3 articles about N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1-Benzyloxycarbonylamino-2-methyl-propyl)-phosphonic acid ethyl ester 2,2,2-trichloro-ethyl ester (87010-57-9) → N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester (87010-64-8)

Guidance literature:

With copper; acetic acid; zinc; In pyridine; for 0.0833333h;

Reference yield:

1-(N-benzyloxycarbonyl)amino-2-methylpropylphosphonic acid (59191-42-3) → N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester (87010-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / trichloroacetonitrile / pyridine / 6 h / 100 °C

2: 90 percent / 80 - 145 °C

3: 84 percent / Zn/Cu, AcOH / pyridine / 0.08 h

With copper; acetic acid; trichloroacetonitrile; zinc; In pyridine;

Reference yield:

N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid 2,2,2-trichloroethyl monoester (87010-53-5) → N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid ethyl monoester (87010-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / 80 - 145 °C

2: 84 percent / Zn/Cu, AcOH / pyridine / 0.08 h

With copper; acetic acid; zinc; In pyridine;

upstream raw materials:

(1-Benzyloxycarbonylamino-2-methyl-propyl)-phosphonic acid ethyl ester 2,2,2-trichloro-ethyl ester

1-(N-benzyloxycarbonyl)amino-2-methylpropylphosphonic acid

N-benzyloxycarbonyl-1-amino-2-methylpropanephosphonic acid 2,2,2-trichloroethyl monoester