C₄₈H₄₀Br₄N₄O₉

Base Information

• Chemical Name: C₄₈H₄₀Br₄N₄O₉
• CAS No.: 845784-25-0
• Molecular Formula: C₄₈H₄₀Br₄N₄O₉
• Molecular Weight: 1136.48
• Mol file: 845784-25-0.mol

Synonyms:C₄₈H₄₀Br₄N₄O₉

Chemical Property of C₄₈H₄₀Br₄N₄O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₄₀Br₄N₄O₉

There total 27 articles about C₄₈H₄₀Br₄N₄O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Bis-(2-benzyloxy-5-formyl-phenyl)-iodonium; bromide (77251-51-5) → C48H40Br4N4O9 (845784-25-0)

Guidance literature:

Multi-step reaction with 17 steps

1.1: imidazole; K₂CO₃ / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 6 h / 80 °C

2.1: 99 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

3.1: 86 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

4.1: 88 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

5.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

5.2: 91 percent / dimethylformamide / 12 h / 0 - 20 °C

6.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

7.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

8.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

9.1: pyridine / ethanol / 20 °C

10.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

11.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

12.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

13.1: 100 percent / NBS / acetonitrile / 1 h / 0 °C

14.1: CoCl₂*6H₂O; NaBH₄ / methanol / 0 °C

14.2: i-Pr₂NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂; dimethylformamide / 0 - 20 °C

15.1: 75 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C

16.1: aq. LiOH / methanol; tetrahydrofuran / 5 h / 0 °C

17.1: TFA / CH₂Cl₂ / 0 °C

17.2: i-Pr₂NEt; PyBOP / CH₂Cl₂; dimethylformamide / 25 h / 0 - 20 °C

17.3: TBAF / tetrahydrofuran / 20 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium hydroxide; sodium hypochlorite; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; pentamethylbenzene,; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; trifluoroacetic acid; cobalt(II) chloride; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2.1: Knoevenagel condensation;

DOI:10.1002/chem.200400904

Reference yield:

4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde (705932-29-2) → C48H40Br4N4O9 (845784-25-0)

Guidance literature:

Multi-step reaction with 16 steps

1.1: 99 percent / piperidine; Ac₂O / tetrahydrofuran / 24 h / 80 °C

2.1: 86 percent / NaBH₄ / methanol; acetonitrile / 4 h / 0 - 20 °C

3.1: 88 percent / NaOMe; BuONO / methanol / 48 h / 0 °C

4.1: imidazole; K₂CO₃ / dimethylformamide / 0.5 h / 0 °C

4.2: 91 percent / dimethylformamide / 12 h / 0 - 20 °C

5.1: 99 percent / aq. HCl / tetrahydrofuran / 20 °C

6.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

7.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

8.1: pyridine / ethanol / 20 °C

9.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

10.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

11.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

12.1: 100 percent / NBS / acetonitrile / 1 h / 0 °C

13.1: CoCl₂*6H₂O; NaBH₄ / methanol / 0 °C

13.2: i-Pr₂NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂; dimethylformamide / 0 - 20 °C

14.1: 75 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C

15.1: aq. LiOH / methanol; tetrahydrofuran / 5 h / 0 °C

16.1: TFA / CH₂Cl₂ / 0 °C

16.2: i-Pr₂NEt; PyBOP / CH₂Cl₂; dimethylformamide / 25 h / 0 - 20 °C

16.3: TBAF / tetrahydrofuran / 20 °C

With piperidine; pyridine; 1H-imidazole; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium hydroxide; sodium hypochlorite; sodium tetrahydroborate; N-Bromosuccinimide; n-Butyl nitrite; pentamethylbenzene,; tetrabutyl ammonium fluoride; sodium methylate; acetic anhydride; potassium carbonate; trifluoroacetic acid; cobalt(II) chloride; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1.1: Knoevenagel condensation;

DOI:10.1002/chem.200400904

Reference yield:

3-{4-Benzyloxy-3-[2-bromo-4-(2,3-dihydroxy-propyl)-phenoxy]-phenyl}-2-[(E)-benzyloxyimino]-propionic acid methyl ester → C48H40Br4N4O9 (845784-25-0)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 88 percent / imidazole / dimethylformamide / 11 h / 0 - 20 °C

2.1: TEMPO; KBr; aq. NaOCl / NaHCO₃ / CH₂Cl₂ / 1 h / 0 °C

3.1: pyridine / ethanol / 20 °C

4.1: 24 percent / TBAF / tetrahydrofuran / 0.5 h / 20 °C

5.1: 97 percent / TEMPO; aq. KBr; NaOCl / NaHCO₃ / acetonitrile / 2 h / 0 °C

6.1: 94 percent / TFA; pentamethylbenzene / 2.5 h / 0 - 20 °C

7.1: 100 percent / NBS / acetonitrile / 1 h / 0 °C

8.1: CoCl₂*6H₂O; NaBH₄ / methanol / 0 °C

8.2: i-Pr₂NEt; 1-hydroxybenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl / CH₂Cl₂; dimethylformamide / 0 - 20 °C

9.1: 75 percent / N-bromosuccinimide / acetonitrile / 2 h / 0 °C

10.1: aq. LiOH / methanol; tetrahydrofuran / 5 h / 0 °C

11.1: TFA / CH₂Cl₂ / 0 °C

11.2: i-Pr₂NEt; PyBOP / CH₂Cl₂; dimethylformamide / 25 h / 0 - 20 °C

11.3: TBAF / tetrahydrofuran / 20 °C

With pyridine; 1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; lithium hydroxide; sodium hypochlorite; sodium tetrahydroborate; N-Bromosuccinimide; pentamethylbenzene,; tetrabutyl ammonium fluoride; trifluoroacetic acid; cobalt(II) chloride; potassium bromide; sodium hydrogencarbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/chem.200400904

upstream raw materials:

4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzaldehyde

2-{4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzylidene}-malonic acid dimethyl ester

2-{4-benzyloxy-3-[2-bromo-4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-phenoxy]-benzyl}-malonic acid dimethyl ester

{2-(tert-butyl-dimethyl-silanyloxy)-2-[3,5-dibromo-4-(5-cyanomethyl-2-hydroxy-phenoxy)-phenyl]-ethyl}-carbamic acid tert-butyl ester