2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine

Base Information

• Chemical Name: 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine
• CAS No.: 1344674-54-9
• Molecular Formula: C₂₅H₂₄ClIN₂
• Molecular Weight: 514.836
• Mol file: 1344674-54-9.mol

Synonyms:2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine

Chemical Property of 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine

There total 4 articles about 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-(3-chlorophenyl)cyclohexan-1-one (1048916-71-7) + 1-(4-iodobenzyl)-1-phenylhydrazine (1344674-97-0) → 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine (1344674-54-9)

Guidance literature:

With acetic acid; In ethanol; at 60 ℃; for 3h;

DOI:10.1021/ja2092163

Reference yield:

8-(3-chlorophenyl)-1,4-dioxaspiro[4.5]decane → 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine (1344674-54-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / tetrahydrofuran; water / Reflux

2: acetic acid / ethanol / 3 h / 60 °C

With hydrogenchloride; acetic acid; In tetrahydrofuran; ethanol; water;

DOI:10.1021/ja2092163

Reference yield:

C14H17ClO3 (1297474-24-8) → 2-(4-(3-chlorophenyl)cyclohexylidene)-1-(4-iodobenzyl)-1-phenylhydrazine (1344674-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 100 °C

2: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 20 °C

3: hydrogenchloride / tetrahydrofuran; water / Reflux

4: acetic acid / ethanol / 3 h / 60 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; toluene;

DOI:10.1021/ja2092163

upstream raw materials:

4-(3-chlorophenyl)cyclohexan-1-one

1-(4-iodobenzyl)-1-phenylhydrazine

C₁₄H₁₇ClO₃