H-P-AMINO-D-PHE-OH HCL

Base Information

• Chemical Name: H-P-AMINO-D-PHE-OH HCL
• CAS No.: 126257-07-6
• Molecular Formula: C₉H₁₂N₂O₂*2ClH
• Molecular Weight: 253.128
• Mol file: 126257-07-6.mol

Synonyms:L-p-aminophenylalanine dihydrochloride;11H-Dibenzo[b,e][1,4]dioxepin-7-carboxylicacid,8-hydroxy-3-methoxy-11-oxo-1-(2-oxopentyl)-6-propyl;loxodellonic acid;

Chemical Property of H-P-AMINO-D-PHE-OH HCL

Chemical Property:

• Melting Point: >215°C (dec.)
• PSA: 89.34000
• LogP: 2.30670
• Storage Temp.: 2-8°C
• Solubility.: H2O: 20 mg/mL, soluble

Purity/Quality:

98%Min ^*data from raw suppliers

4-Amino-D-phenylalanineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-D-phenylalanine Hydrochloride is used as a reagent in the synthesis of D-Melphalan (M216915); an isomer of Melphalan (M216900) which is an antineoplastic.

Technology Process of H-P-AMINO-D-PHE-OH HCL

There total 2 articles about H-P-AMINO-D-PHE-OH HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-3-phenyl-L-alanine (949-99-5) → L-p-aminophenylalanine dihydrochloride (62040-55-5,93913-56-5,120482-21-5,126257-07-6,139879-21-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on barium sulfate; In water; for 4h; under 760 Torr;

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → L-p-aminophenylalanine dihydrochloride (62040-55-5,93913-56-5,120482-21-5,126257-07-6,139879-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid, nitric acid / 1) room temperature, 24 h, 2) 50 deg C (bath temperature), 2 h

2: H₂, HCl / Pd-BaSO₄ / H₂O / 4 h / 760 Torr

With hydrogenchloride; sulfuric acid; hydrogen; nitric acid; palladium on barium sulfate; In water;

upstream raw materials:

4-nitro-3-phenyl-L-alanine

L-phenylalanine