Fmoc-3-iodo-L-tyrosine

Base Information

Chemical Name:Fmoc-3-iodo-L-tyrosine
CAS No.:134486-00-3
Molecular Formula:C24H20 I N O5
Molecular Weight:529.331
Hs Code.:
European Community (EC) Number:695-207-1
DSSTox Substance ID:DTXSID20446663
Nikkaji Number:J1.351.440B
Wikidata:Q82265377
Mol file:134486-00-3.mol

Synonyms:Fmoc-3-iodo-L-tyrosine;134486-00-3;Fmoc-3-iodo-Tyr-OH;Fmoc-Tyr(3-I)-OH;Fmoc-L-Tyr(3-I)-OH;L-Tyrosine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-hydroxy-3-iodophenyl)propanoic acid;(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propanoic acid;C24H20INO5;SCHEMBL2030857;SCHEMBL14584328;DTXSID20446663;MFCD00235906;AKOS015837217;AKOS015907961;AC-27954;AS-10396;CS-0100996;E70515;EN300-7363350;J-006545;L-Tyrosine,N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-;N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-3-iodo-tyrosine;N-(9H-Fluorene-9-ylmethoxycarbonyl)-3-iodo-4-hydroxy-L-phenylalanine;(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4-hydroxy-3-iodophenyl)propanoic acid;(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(4-hydroxy-3-iodophenyl)propanoic acid

Suppliers and Price of Fmoc-3-iodo-L-tyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Fmoc-3-iodo-L-tyrosine
500mg
$ 347.00

Usbiological
Fmoc-3-iodo-L-tyrosine
25mg
$ 305.00

TRC
Fmoc-3-iodo-L-tyrosine
25mg
$ 45.00

Matrix Scientific
Fmoc-3-iodo-L-tyrosine
5g
$ 400.00

Matrix Scientific
Fmoc-3-iodo-L-tyrosine
1g
$ 179.00

Iris Biotech GmbH
Fmoc-L-Tyr(3-I)-OH
1 g
$ 270.00

Iris Biotech GmbH
Fmoc-L-Tyr(3-I)-OH
5 g
$ 1080.00

Crysdot
Fmoc-Tyr(3-I)-OH 97%
25g
$ 1500.00

Crysdot
Fmoc-Tyr(3-I)-OH 97%
5g
$ 400.00

Crysdot
Fmoc-Tyr(3-I)-OH 97%
10g
$ 760.00

Total 36 raw suppliers

Chemical Property of Fmoc-3-iodo-L-tyrosine

Chemical Property:

Boiling Point:675.7±55.0 °C(Predicted)
PKA:2.86±0.10(Predicted)
PSA：95.86000
Density:1.634±0.06 g/cm3(Predicted)
LogP:4.92210
Storage Temp.:2-8°C
Solubility.:DMF (Slightly), Methanol (Slightly)
XLogP3:4.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:529.03862
Heavy Atom Count:31
Complexity:624

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-3-iodo-L-tyrosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=CC(=C(C=C4)O)I)C(=O)O
Isomeric SMILES:C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC4=CC(=C(C=C4)O)I)C(=O)O
Uses Fmoc-3-iodo-l-tyrosine acts as a reagent in the synthesis of antitumor rubiyunnanin B dityrosine core by Suzuki coupling.

Technology Process of Fmoc-3-iodo-L-tyrosine

There total 2 articles about Fmoc-3-iodo-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 112883-29-1,92954-90-0
N-Fmoc-Tyr-OH

: 134486-00-3,244028-70-4
(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propionic acid

Guidance literature:: With tetrafluoroboric acid; Barluenga reagent; In dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1039/b003064n

Reference yield: 82.0%

: 70-78-0
3-Iodo-L-tyrosine

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 134486-00-3,244028-70-4
(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propionic acid

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetone; at 20 ℃;
DOI:10.1021/jm050376t

Reference yield:

: C₂₈H₂₉N₂O₄Pol

: 29022-11-5
N-(fluoren-9-ylmethoxycarbonyl)glycine

: 71989-31-6
Fmoc-Pro-OH

: Fmoc-Gln(Trt)-OH

: 103213-32-7,167015-11-4
N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine

: 71989-35-0,138797-71-4
Fmoc-Thr(tBu)-OH

: 134486-00-3,244028-70-4
(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propionic acid

: 133174-15-9
(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid

: 204777-78-6
Fmoc-Lys(ivDde)-OH

: 187618-60-6
Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

: Fmoc-Glu(ODmab)-OH

: C₆₇H₁₀₀IN₂₁O₂₁S₂

Guidance literature:: C₂₈H₂₉N₂O₄Pol; With piperidine; In N,N-dimethyl-formamide; Rink amide MBHA resin

Fmoc-Lys(ivDde)-OH; With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 2.5h; Rink amide MBHA resin

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-Pro-OH; Fmoc-Gln(Trt)-OH; N-(9-fluorenylmethoxycarbonyl)-S-trityl-L-cysteine; Fmoc-Thr(tBu)-OH; (S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxy-3-iodophenyl)propionic acid; (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-ureidopentanoic acid; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Fmoc-Glu(ODmab)-OH; Further stages;