(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

Base Information

Chemical Name:(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one
CAS No.:1413627-00-5
Molecular Formula:C₂₃H₂₈O₅
Molecular Weight:384.472
Hs Code.:

Synonyms:(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

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Chemical Property of (3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

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Technology Process of (3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

There total 10 articles about (3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1413626-96-6
2-((4R,6S)-4-(benzyloxy)-6-hydroxyheptyl)-4,6-dimethoxybenzoic acid

: 1413627-00-5
(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.09.032

Reference yield:

: 1413626-88-6
C₂₀H₂₈O₅

: 1413627-00-5
(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-aniline / 48 h / 180 °C / Sealed tube

2: methanol; sodium hydroxide / 8 h / 110 °C

3: hydrogenchloride / water / 3 h / 0 - 20 °C

4: diethylazodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; N,N-dimethyl-aniline; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In water; toluene; 4: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2012.09.032

Reference yield:

: 1413626-92-2
methyl 2-((4R,6S)-4-(benzyloxy)-6-(methoxymethoxy)heptyl)-4,6-dimethoxybenzoate

: 1413627-00-5
(3R,5R)-5-(benzyloxy)-10,12-dimethoxy-3-methyl-3,4,5,6,7,8-hexahydro-1H-2-benzoxecin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: methanol; sodium hydroxide / 8 h / 110 °C

2: hydrogenchloride / water / 3 h / 0 - 20 °C

3: diethylazodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In water; toluene; 3: |Mitsunobu Displacement;
DOI:10.1016/j.tetlet.2012.09.032