Cyclohexanecarboxylicacid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, cis-

Base Information

• Chemical Name: Cyclohexanecarboxylicacid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, cis-
• CAS No.: 147900-45-6
• Molecular Formula: C22H23NO4
• Molecular Weight: 365.42
• Hs Code.: 29242990
• European Community (EC) Number: 847-114-4,847-145-3
• Mol file: 147900-45-6.mol

Synonyms:trans-4-(Fmoc-amino)cyclohexanecarboxylic acid;

Chemical Property of Cyclohexanecarboxylicacid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, cis-

Chemical Property:

• Boiling Point: 596.9 °C at 760 mmHg
• PKA: 4.87±0.25(Predicted)
• Flash Point: 314.8 °C
• PSA: 75.63000
• Density: 1.29 g/cm³
• LogP: 4.55940
• Storage Temp.: 2-8°C
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 365.16270821
• Heavy Atom Count: 27
• Complexity: 520

Purity/Quality:

99% ^*data from raw suppliers

Fmoc-cis-4-aminocyclohexane carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(CCC1C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Technology Process of Cyclohexanecarboxylicacid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, cis-

There total 3 articles about Cyclohexanecarboxylicacid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cis-4-aminocyclohexane-1-carboxylic acid (3685-23-2) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 4-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclohexanecarboxylic acid (147900-45-6)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; for 16h;

DOI:10.1021/ja034440c

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclohexanecarboxylic acid (147900-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / ethanol; H₂O / 2585.7 Torr / Ambient temperature

2: 1.) NaOH, 2.) NaHCO₃ / 1.) THF, H₂O, 5 min, 2.) THF, H₂O

With sodium hydroxide; hydrogen; sodium hydrogencarbonate; platinum(IV) oxide; In ethanol; water;

DOI:10.1021/jm00060a018

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-(9H-fluoren-9-ylmethoxycarbonylamino)-cyclohexanecarboxylic acid (147900-45-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / PtO₂ / 2585.74 Torr

2: TEA, NaOH / dimethylformamide / 20 °C

With sodium hydroxide; TEA; hydrogen; platinum(IV) oxide; In N,N-dimethyl-formamide;

upstream raw materials:

cis-4-aminocyclohexane-1-carboxylic acid

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

4-amino-benzoic acid

Downstream raw materials:

C₅₃H₆₂N₉O₁₇PS

C₃₃H₄₀N₈O₆

C₃₃H₄₁N₇O₄

C₃₄H₄₀F₃N₇O₄

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