(2H₅)benzoylecgonine methyl ester

Base Information

• Chemical Name: (2H₅)benzoylecgonine methyl ester
• CAS No.: 762227-69-0
• Molecular Formula: C₁₇H₂₁NO₄
• Molecular Weight: 308.318
• Mol file: 762227-69-0.mol

Synonyms:(2H₅)benzoylecgonine methyl ester

Chemical Property of (2H₅)benzoylecgonine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2H₅)benzoylecgonine methyl ester

There total 4 articles about (2H₅)benzoylecgonine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

benzoyl chloride-d5 (43019-90-5) + methyl ecgonine (7143-09-1) → (2H5)benzoylecgonine methyl ester (762227-69-0)

Guidance literature:

With triethylamine; In chloroform; for 24h; Heating;

DOI:10.1002/(SICI)1099-1344(19991230)42:13<1265::AID-JLCR283>3.0.CO;2-Y

Reference yield:

benzoic acid-2,3,4,5,6-d5 (1079-02-3) → (2H5)benzoylecgonine methyl ester (762227-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / thionyl chloride; sodium chloride / Heating

2: 94.9 percent / triethylamine / CHCl₃; various solvent(s) / 24 h / Heating

With thionyl chloride; triethylamine; sodium chloride; In chloroform; 1: Substitution / 2: Condensation;

DOI:10.1002/(SICI)1099-1344(19991230)42:13<1265::AID-JLCR283>3.0.CO;2-Y

Reference yield:

ecgonine hydrochloride (5796-31-6) → (2H5)benzoylecgonine methyl ester (762227-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / hydrogen chloride / 24 h / Heating

2: 94.9 percent / triethylamine / CHCl₃; various solvent(s) / 24 h / Heating

With hydrogenchloride; triethylamine; In chloroform; 1: Methylation / 2: Condensation;

DOI:10.1002/(SICI)1099-1344(19991230)42:13<1265::AID-JLCR283>3.0.CO;2-Y

upstream raw materials:

benzoyl chloride-d5

methyl ecgonine

benzoic acid-2,3,4,5,6-d5

ecgonine hydrochloride

Downstream raw materials:

(2H₅)benzoylecgonine