N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Base Information

Chemical Name:N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide
CAS No.:446234-39-5
Molecular Formula:C₂₀H₂₉N₅O₄S
Molecular Weight:435.547
Hs Code.:

N<sup>1</sup>-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Synonyms:N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

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Chemical Property of N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Chemical Property:

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Technology Process of N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

There total 7 articles about N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 446234-39-5
N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

2: tetrahydrofuran; diethyl ether / -78 - 20 °C

3: aq. NaOH / ethanol / 3 h / Heating

4: pyridine / 20 °C

5: aq. NaOH / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jf0200624

Reference yield:

: 446234-38-4
N⁴-acetyl{N¹-[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

: 446234-39-5
N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Guidance literature:: With sodium hydroxide; at 20 ℃;
DOI:10.1021/jf0200624

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 446234-39-5
N¹-{[4-(5-N-tert-butoxycarbonylamino)pentyl]-2-pyrimidyl}-sulfanilamide

Guidance literature:: Multi-step reaction with 6 steps

1: aq. NaOH / dioxane / 5 h

2: 4-methylmorpholine; isobutyl chloroformate; triethylamine / tetrahydrofuran; dimethylformamide / -15 - 20 °C

3: tetrahydrofuran; diethyl ether / -78 - 20 °C

4: aq. NaOH / ethanol / 3 h / Heating

5: pyridine / 20 °C

6: aq. NaOH / 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; triethylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jf0200624