benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

Base Information

Chemical Name:benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate
CAS No.:1234577-38-8
Molecular Formula:C₂₇H₃₇NO₃Si
Molecular Weight:451.681
Hs Code.:

Synonyms:benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

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Technology Process of benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

There total 1 articles about benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 621-84-1
O-benzyl carbamate

: 807616-80-4
(RS)-1-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-ol

: 1234577-38-8
benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

Guidance literature:: With potassium hexafluorophosphate; bismuth(lll) trifluoromethanesulfonate; magnesium sulfate; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol101295t

Reference yield: 86.0%

: 75-11-6
diiodomethane

: 1234577-38-8
benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

: benzyl (1RS,2SR,6RS)-{5-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]bicyclo[4.1.0]heptan-2-yl}carbamate

Guidance literature:: diiodomethane; With diethylzinc; In hexane; dichloromethane; at -78 - 0 ℃; Inert atmosphere;

benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate; In hexane; dichloromethane; at 20 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol101295t

Reference yield: 57.0%

: 75-11-6
diiodomethane

: 1234577-38-8
benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate

: benzyl (RS,RS,RS)-{5-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]bicyclo[4.1.0]heptan-2-yl}carbamate

Guidance literature:: diiodomethane; With diethylzinc; In hexane; dichloromethane; at -78 - 0 ℃; Inert atmosphere;

With trifluoroacetic acid; In hexane; dichloromethane; for 0.25h; Inert atmosphere;

benzyl (RS)-{3-[4'-(tert-butyldimethylsilyloxymethyl)phenyl]cyclohex-2-en-1-yl}carbamate; In hexane; dichloromethane; at 20 ℃; for 3h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol101295t