Technology Process of C14H16F2
There total 4 articles about C14H16F2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile);
In
benzene;
at 80 ℃;
for 12h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol500803r
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diethylene glycol dimethyl ether / 0.5 h / 20 - 180 °C / Inert atmosphere
2: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere
3: pyridine; triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
4: 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 80 °C / Inert atmosphere
With
pyridine; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; potassium carbonate; triphenylphosphine;
In
methanol; dichloromethane; diethylene glycol dimethyl ether; benzene;
DOI:10.1021/ol500803r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine; triphenylphosphine; carbon tetrabromide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
2: 2,2'-azobis(isobutyronitrile) / benzene / 12 h / 80 °C / Inert atmosphere
With
pyridine; 2,2'-azobis(isobutyronitrile); carbon tetrabromide; triphenylphosphine;
In
dichloromethane; benzene;
DOI:10.1021/ol500803r