Technology Process of 7-(3,4-difluorophenyl)-2-pentyl-2,3,4,9-tetrahydro-1H-fluorene
There total 5 articles about 7-(3,4-difluorophenyl)-2-pentyl-2,3,4,9-tetrahydro-1H-fluorene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; sodium carbonate; triphenylphosphine;
In
ethanol; water; toluene;
at 80 ℃;
for 24h;
DOI:10.1080/15421406.2011.570542
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / chloroform / 0.17 h / 5 - 10 °C
1.2: 20 - 60 °C
2.1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 3 h / 45 °C
3.1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C
4.1: polyphosphoric acid (PPA) / 0.33 h / 135 - 137 °C
5.1: palladium 10% on activated carbon; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 24 h / 80 °C
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; tetrabutylammomium bromide; palladium diacetate; sodium carbonate; potassium carbonate; triphenylphosphine; trichlorophosphate;
In
diethyl ether; ethanol; chloroform; water; toluene;
2.1: Suzuki coupling;
DOI:10.1080/15421406.2011.570542
- Guidance literature:
-
Multi-step reaction with 3 steps
1: lithium aluminium tetrahydride / diethyl ether / 1 h / 0 °C
2: polyphosphoric acid (PPA) / 0.33 h / 135 - 137 °C
3: palladium 10% on activated carbon; sodium carbonate; triphenylphosphine / ethanol; water; toluene / 24 h / 80 °C
With
lithium aluminium tetrahydride; palladium 10% on activated carbon; sodium carbonate; triphenylphosphine;
In
diethyl ether; ethanol; water; toluene;
DOI:10.1080/15421406.2011.570542
