6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

Base Information

Chemical Name:6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester
CAS No.:146953-68-6
Molecular Formula:C₃₇H₆₀N₆O₁₂
Molecular Weight:780.916
Hs Code.:

6-<N-<(ethoxycarbonyl)methyl>-N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

Synonyms:6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

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Chemical Property of 6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

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Technology Process of 6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

There total 4 articles about 6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4741-99-5
3,7-diazanonane-1,9-diamine

: 146953-68-6
6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / Heating

2: 1) BH₃*THF, 2) concd. HCl / 1) THF, reflux, 2) H₂O, reflux

3: 75 percent / 1 M HCl/MeOH, NaBH₃CN / 3 h / Ambient temperature

4: 1) K₂CO₃ / 1) DMF, r. t., 1 h, 2) r. t., 3 h

With hydrogenchloride; methanol; borane-THF; sodium cyanoborohydride; potassium carbonate; In methanol;
DOI:10.1021/jo00059a062

Reference yield:

: 146953-65-3
6-amino-1,4,8,11-tetraazacyclotetradecane

: 146953-68-6
6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / 1 M HCl/MeOH, NaBH₃CN / 3 h / Ambient temperature

2: 1) K₂CO₃ / 1) DMF, r. t., 1 h, 2) r. t., 3 h

With hydrogenchloride; methanol; sodium cyanoborohydride; potassium carbonate;
DOI:10.1021/jo00059a062

Reference yield:

: 148584-64-9
6-amino-cyclam-5,7-dione

: 146953-68-6
6--N-(4-nitrobenzyl)amino>-1,4,8,11-tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetraethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) BH₃*THF, 2) concd. HCl / 1) THF, reflux, 2) H₂O, reflux

2: 75 percent / 1 M HCl/MeOH, NaBH₃CN / 3 h / Ambient temperature

3: 1) K₂CO₃ / 1) DMF, r. t., 1 h, 2) r. t., 3 h

With hydrogenchloride; methanol; borane-THF; sodium cyanoborohydride; potassium carbonate;
DOI:10.1021/jo00059a062