(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Base Information

Chemical Name:(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
CAS No.:1321622-37-0
Molecular Formula:C₃₂H₅₅N₅O₅
Molecular Weight:589.819
Hs Code.:

(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Synonyms:(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

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Technology Process of (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

There total 7 articles about (2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.3%

: 1321622-89-2
(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

: 1321622-37-0
(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; ethanolamine; In tert-butyl methyl ether; at 25 ℃;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 111992-61-1
2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione

: 1321622-37-0
(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 100 °C

2: hydrazine hydrate / ethanol / 4 h / 80 °C

3: copper(ll) sulfate pentahydrate; triethylamine / dichloromethane; water / 2 h

4: 2-hydroxypyridin; triethylamine / 65 °C

5: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; sodium azide; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; ethanolamine; triethylamine; In ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 1321622-18-7
2-(3-azido-2,2-dimethylpropyl)isoindoline-1,3-dione

: 1321622-37-0
(2S,4S,5S,7S)-5-amino-N-(2,2-dimethyl-3-(1H-1,2,3-triazol-1-yl)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 4 h / 80 °C

2: copper(ll) sulfate pentahydrate; triethylamine / dichloromethane; water / 2 h

3: 2-hydroxypyridin; triethylamine / 65 °C

4: palladium 10% on activated carbon; hydrogen; ethanolamine / tert-butyl methyl ether / 25 °C

With 2-hydroxypyridin; copper(ll) sulfate pentahydrate; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; ethanolamine; triethylamine; In ethanol; dichloromethane; tert-butyl methyl ether; water;
DOI:10.1016/j.bmc.2011.05.059