FMOC-PHE(3-I)-OH

Base Information

• Chemical Name: FMOC-PHE(3-I)-OH
• CAS No.: 210282-31-8
• Molecular Formula: C24H20 I N O4
• Molecular Weight: 513.332
• Hs Code.: 2924299090
• Mol file: 210282-31-8.mol

Synonyms:Fmoc-Phe(3-I)-OH;Fmoc-3-iodo-L-phenylalanine;(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-iodophenyl)propanoic acid;Fmoc-(3-I)Phe-OH;N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-phenylalanine;

Chemical Property of FMOC-PHE(3-I)-OH

Chemical Property:

• Boiling Point: 674.1±55.0 °C(Predicted)
• PKA: 3.71±0.10(Predicted)
• PSA: 75.63000
• Density: 1.577±0.06 g/cm3(Predicted)
• LogP: 5.21650
• Storage Temp.: Store at 0-5°C

Purity/Quality:

97% ^*data from raw suppliers

Fmoc-phe(3-I)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMOC-PHE(3-I)-OH

There total 1 articles about FMOC-PHE(3-I)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1,1-dimethylethyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-iodo-L-phenylalaninate → (S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4)

Guidance literature:

With trifluoroacetic acid; at 20 ℃;

DOI:10.1016/S0040-4020(01)00554-3

Reference yield: 99.0%

(S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) + (S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4) → C36H32IN3O5

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Sealed tube;

DOI:10.1002/chem.201601832

Reference yield: 79.0%

2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (72824-04-5) + (S)-2-((((9H-fluoren-9-yl)methoxy)-carbonyl)amino)-3-(3-iodophenyl)propanoic acid (210282-31-8,478183-67-4) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-allylphenyl)propanoic acid

Guidance literature:

With potassium phosphate; [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][butylbis(tricyclo-[3.3.1.13,7]dec-1-yl)phosphine]chloropalladium; cesium fluoride; In 1,4-dioxane; water; at 110 ℃; for 0.583333h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01599

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