(S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine

Base Information

• Chemical Name: (S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine
• CAS No.: 1438883-31-8
• Molecular Formula: C₂₅H₂₈BrN₅OS
• Molecular Weight: 526.5

Synonyms:(S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine

Chemical Property of (S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine

Chemical Property:

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Technology Process of (S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine

There total 2 articles about (S)-N₁-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4,6-triisopropylbenzenesulfonic acid 7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl ester (1438887-52-5) + [(S)-2-amino-1-(2-methoxybenzyl)ethyl]carbamic acid tert-butyl ester → (S)-N1-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine (1438883-31-8)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide; at 20 ℃; for 2h;

Reference yield:

(S)-2-tert-butoxycarbonylamino-3-(2-methoxyphenyl)propionic acid (143415-63-8) → (S)-N1-(7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl)-3-(2-methoxyphenyl)propane-1,2-diamine (1438883-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine; di-tert-butyl dicarbonate; ammonium carbonate / 1,4-dioxane / 4 h / 20 °C

2.1: borane-THF / tetrahydrofuran / 20 °C

2.2: 2 h / 20 °C

3.1: triethylamine / N,N-dimethyl acetamide / 2 h / 20 °C

With pyridine; borane-THF; di-tert-butyl dicarbonate; ammonium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide;

upstream raw materials:

(S)-2-tert-butoxycarbonylamino-3-(2-methoxyphenyl)propionic acid

2,4,6-triisopropylbenzenesulfonic acid 7-bromo-6-tert-butyl-2-pyridin-4-ylthieno[3,2-d]pyrimidin-4-yl ester

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