C₂₃H₂₁NO₃

Base Information

• Chemical Name: C₂₃H₂₁NO₃
• CAS No.: 1175713-06-0
• Molecular Formula: C₂₃H₂₁NO₃
• Molecular Weight: 359.425
• Mol file: 1175713-06-0.mol

Synonyms:C₂₃H₂₁NO₃

Chemical Property of C₂₃H₂₁NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₃H₂₁NO₃

There total 1 articles about C₂₃H₂₁NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-naphthalenylmagnesium bromide (21473-01-8) → C23H21NO3 (1175713-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / -15 °C

1.2: -15 - 20 °C

2.1: hydrogenchloride; acetic acid; tin(ll) chloride / 1 h / 20 °C / Reflux

3.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.5 h / -40 °C

With hydrogenchloride; ethylmagnesium bromide; sodium hydride; acetic acid; tin(ll) chloride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ol200550y

Reference yield: 99.0%

C23H21NO3 (1175713-06-0) → (S)-tert-butyl 3-chloro-3-(naphthalen-2-yl)-2-oxoindoline-1-carboxylate (1273020-52-2)

Guidance literature:

With N-chloro-succinimide; Ca[(S)-VAPOL-Phosphate]2; In Isopropyl acetate; at 20 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja109824x

Reference yield: 98.0%

C23H21NO3 (1175713-06-0) + N-phenylthiophthalimide (14204-27-4) → (S)-tert-butyl 3-(naphthalen-2-yl)-2-oxo-3-(phenylthio)indoline-1-carboxylate

Guidance literature:

With C₇₀H₇₅N₄O₄P; In 1,3,5-trimethyl-benzene; at 25 ℃; for 24h; enantioselective reaction;

DOI:10.1055/s-0035-1560435

upstream raw materials:

2-naphthalenylmagnesium bromide

Downstream raw materials:

C₃₁H₂₈N₂O₅

C₃₁H₂₈N₂O₅

tert-butyl (S)-3-(benzoyloxy)-3-(naphthalen-2-yl)-2-oxoindoline-1-carboxylate

(S)-tert-butyl 3-chloro-3-(naphthalen-2-yl)-2-oxoindoline-1-carboxylate