(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Base Information

Chemical Name:(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester
CAS No.:1192128-09-8
Molecular Formula:C₂₆H₃₀N₂O₄
Molecular Weight:434.535
Hs Code.:

Synonyms:(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

There total 6 articles about (E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₅BrN₂O₂

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1192128-09-8
(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 100 ℃; for 8h;
DOI:10.1021/jm200146u

Reference yield:

: 1192127-60-8
1'-benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4'-piperidine]

: 1192128-09-8
(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1 h / -10 - 20 °C

2: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 8 h / 100 °C

With sulfuric acid; palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 1: Ritter reaction / 2: Heck reaction;
DOI:10.1021/jm200146u

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1192128-09-8
(E)-3-{1'-benzyl-4-acetylamino-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyrrolidine / methanol / Reflux

2: sodium tetrahydroborate / methanol / 3 h / 20 °C

3: sulfuric acid / 1 h / -10 - 20 °C

4: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 8 h / 100 °C

With pyrrolidine; sodium tetrahydroborate; sulfuric acid; palladium diacetate; triethylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide; 3: Ritter reaction / 4: Heck reaction;
DOI:10.1021/jm200146u