<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:122648-68-4
Molecular Formula:C₂₅H₂₉N₃O₈S
Molecular Weight:531.587
Hs Code.:

<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Synonyms:<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of <<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of <<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 5 articles about <<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [2S-(2α,5α,6β)]-3-[[[[[3,3-Dimethyl-7-oxo-6-[(2,6-dimethoxy)benzamido]-4-thia-1-azabicyclo[3.2.0]hept-2-yl]carbonyl]oxy]methoxy]carbonyl]-1-methylpyridinium iodide

: 122648-68-4
<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield:

: <2S-(2α,5α,6β)>-3-<<<<<3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>hept-2-yl>carbonyl>oxy>methoxy>carbonyl>-1-methylpyridinium iodide

: 122648-68-4
<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With sodium dithionite; sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 5 ℃; for 1.16667h;
DOI:10.1021/jm00128a021

Reference yield:

: 132-92-3
methicillin sodium

: 122648-68-4
<<(1,4-dihydro-1-methyl-3-pyridinyl)carbonyl>oxy>methyl <2S-(2α,5α,6β)>-3,3-dimethyl-7-oxo-6-(2,6-dimethoxybenzamido)-4-thia-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 4.24 g / NaHCO₃, tetrabutylammonium hydrogen sulfate / H₂O; CH₂Cl₂ / 0.5 h / below 30 deg C

2: 3 g / dimethylformamide / 144 h / Ambient temperature

3: 1.6 g / nitromethane / 168 h / 20 - 25 °C

4: 0.25 g / Na₂S₂O₄, NaHCO₃ / ethyl acetate; H₂O / 1.17 h / 0 - 5 °C

With sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In nitromethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00128a021