N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1313407-50-9
Molecular Formula:C₂₉H₂₇N₇O₂
Molecular Weight:505.579
Hs Code.:

Synonyms:N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

There total 12 articles about N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313409-79-8
C₂₉H₂₅N₇O₂

: 1313407-50-9
N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With hydrogen; 20% palladium hydroxide-activated charcoal; In methanol; for 2h; Inert atmosphere;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1313407-50-9
N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2.2: 0 °C / Molecular sieve

3.1: thionyl chloride / dichloromethane / 3 h

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

5.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

5.2: 0.5 h / Reflux

6.1: tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 80 °C

6.2: 20 °C

7.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; isopropyl alcohol / 5 h / 86 °C

8.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h / Inert atmosphere

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; iron; potassium carbonate; ammonium chloride; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1313407-50-9
N-(3-ethyl-1-((1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 38 h / 5 - 25 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

3.1: iron; ammonium chloride / ethanol; water / 3 h / 80 °C

3.2: 0.5 h / Reflux

4.1: tetrahydrofuran; 1,2-dichloro-ethane / 2 h / 80 °C

4.2: 20 °C

5.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; isopropyl alcohol / 5 h / 86 °C

6.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2 h / Inert atmosphere

With hydrogen; iodine; iron; potassium carbonate; ammonium chloride; triethylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 20% palladium hydroxide-activated charcoal; In tetrahydrofuran; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; isopropyl alcohol;