3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

Base Information

Chemical Name:3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid
CAS No.:1152131-79-7
Molecular Formula:C₂₈H₁₉ClFN₃O₄
Molecular Weight:515.928
Hs Code.:

Synonyms:3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

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Chemical Property of 3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

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Technology Process of 3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

There total 11 articles about 3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1152131-75-3
3-(5-{4-[3-chloro-4-(3-fluorobenzyloxy)phenylamino]quinazolin-6-yl}furan-2-yl)acrylic acid tert-butyl ester

: 1152131-79-7
3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 0.5h;

Reference yield: 99.0%

: 1257665-55-6
3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid tert-butyl ester

: 1152131-79-7
3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

Guidance literature:: 3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃; for 0.5h; Inert atmosphere;

With ammonium hydroxide; pH=7; Inert atmosphere;
DOI:10.1021/jm100665z

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 1152131-79-7
3-[5-{4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)quinazolin-6-yl}furan-2-yl]acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1 h / Heating; Inert atmosphere

2.1: bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 60 °C / Inert atmosphere

3.1: triethylamine; sodium hydroxide / dichloromethane; water / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / 0.5 h / 20 °C / Inert atmosphere

4.2: pH 7 / Inert atmosphere

With bis(triphenylphosphine)palladium(II) dichloride; sodium carbonate; triethylamine; trifluoroacetic acid; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2.1: Suzuki coupling / 3.1: Wittig reaction;
DOI:10.1021/jm100665z