methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

Base Information

Chemical Name:methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate
CAS No.:889857-59-4
Molecular Formula:C₁₇H₂₄ClNO₅
Molecular Weight:357.834
Hs Code.:

Synonyms:methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

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Chemical Property of methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

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Technology Process of methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

There total 2 articles about methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889858-24-6
methyl (2R)-3-amino-2-(5-chloro-2-methoxybenzyl)propanoate tosylate

: 24424-99-5
di-tert-butyl dicarbonate

: 889857-59-4
methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

Reference yield:

: C₁₂H₁₆ClNO₃

: 24424-99-5
di-tert-butyl dicarbonate

: 889857-59-4
methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2007.03.038

Reference yield:

: 889857-59-4
methyl (2R)-3-[(tert-butoxycarbonyl)amino]-2-(5-chloro-2-methoxybenzyl)propanoate

: C₂₂H₂₆Cl₂N₂O₆S

Guidance literature:: Multi-step reaction with 2 steps

1: aq. KOH / methanol / 3 h / 20 °C

2: EDCI*HCl; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; potassium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2007.03.038