N-CARBOBENZOXY-DL-ASPARTIC ACID

Base Information

• Chemical Name: N-CARBOBENZOXY-DL-ASPARTIC ACID
• CAS No.: 4515-21-3
• Molecular Formula: C12H13NO6
• Molecular Weight: 267.238
• Hs Code.: 29225090
• Mol file: 4515-21-3.mol

Synonyms:Asparticacid, N-carboxy-, N-benzyl ester, DL- (8CI);DL-Aspartic acid,N-[(phenylmethoxy)carbonyl]-;2-[[Benzyloxycarbonyl]amino]succinic acid;N-(Benzyloxycarbonyl)-DL-aspartic acid;

Chemical Property of N-CARBOBENZOXY-DL-ASPARTIC ACID

Chemical Property:

• Melting Point: 115oC
• Boiling Point: 472.8 °C at 760 mmHg
• PKA: 3.75±0.23(Predicted)
• Flash Point: 239.7 °C
• PSA: 112.93000
• Density: 1.404 g/cm³
• LogP: 1.23160
• Storage Temp.: Store at RT.

Purity/Quality:

min 98.0% ^*data from raw suppliers

Z-DL-aspartic acid 99+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-CARBOBENZOXY-DL-ASPARTIC ACID

There total 3 articles about N-CARBOBENZOXY-DL-ASPARTIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl chloroformate (501-53-1,94274-21-2) + aspartic Acid (617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → N-benzyloxycarbonylaspartic acid (4515-21-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00377

Reference yield:

aspartic Acid (617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → N-benzyloxycarbonylaspartic acid (4515-21-3)

Guidance literature:

With water; magnesium oxide; benzyl chloroformate; Reagens 4: Aether;

Reference yield:

→ N-benzyloxycarbonylaspartic acid (4515-21-3)

Guidance literature:

DL-Asparaginsaeure nach Bergemann u. Zerras, B.65<1932>1192, unter Verwendung v. reaktionsfaehigem MgO (Eiskuehlung, 1/2d);

upstream raw materials:

aspartic Acid

benzyl chloroformate

Downstream raw materials:

N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester-L-phenylalanine methyl ester complex

N-carbobenzyloxy-L-aspartyl-L-phenylalanine methyl ester

2-benzyloxycarbonylamino-acrylic acid

N-Cbz-L-Asp

Refernces

• 1、 -. "Compound with TNF-alpha inhibition activity and application thereof". Paragraph 0006. . Retrieved 2020/07/13.
• 2、 -. "DNA Methyltransferase inhibitors". Page 15-16. . Retrieved 2008/06/13.