4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole

Base Information

• Chemical Name: 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole
• CAS No.: 155883-53-7
• Molecular Formula: C₂₀H₁₇N₃O
• Molecular Weight: 315.374

Synonyms:4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole

Chemical Property of 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole

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Technology Process of 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole

There total 3 articles about 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-phenyl-4H-pyrazolo<1,5-a>indole (60230-72-0) → 3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole + 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole (155883-53-7)

Guidance literature:

With trichlorophosphate; at 20 - 60 ℃; for 3h; Mechanism; other 4H-pyrazolo<1,5-a>indole derivatives, var. time;

DOI:10.1248/cpb.42.237

Reference yield:

2-phenyl-4H-pyrazolo<1,5-a>indole (60230-72-0) → 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole (155883-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / molecular sieves 4A / 20 h / Heating

2: 1.) POCl₃ / 1.) RT, 1 h, 2.) RT, 30 min

With 4 A molecular sieve; trichlorophosphate;

DOI:10.1248/cpb.42.237

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 4-((Z)-dimethylaminomethylene)-2-phenyl-4H-pyrazolo<1,5-a>indole (155883-66-2) → 4-((E)-dimethylaminomethylene)-3-formyl-2-phenyl-4H-pyrazolo<1,5-a>indole (155883-53-7)

Guidance literature:

With trichlorophosphate; Yield given. Multistep reaction; 1.) RT, 1 h, 2.) RT, 30 min;

DOI:10.1248/cpb.42.237

upstream raw materials:

N,N-dimethyl-formamide

2-phenyl-4H-pyrazolo<1,5-a>indole

4-((Z)-dimethylaminomethylene)-2-phenyl-4H-pyrazolo<1,5-a>indole

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