2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

Base Information

Chemical Name:2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride
CAS No.:71621-30-2
Molecular Formula:C₁₉H₂₃NO₃*ClH
Molecular Weight:349.857
Hs Code.:

Synonyms:2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

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Technology Process of 2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

There total 17 articles about 2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 71621-15-3
2-[(4-methyl-morpholin-2-yl)-phenyl-methoxy]-phenol

: alcoholic HCl

CH₃ I: CH₃ I

: 584-08-7
potassium carbonate

: 71621-30-2
2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

Guidance literature:: In water; N,N-dimethyl-formamide;

Reference yield: 58.0%

: 93852-97-2,93852-98-3
2-[(2-Methoxy-phenoxy)-phenyl-methyl]-morpholine-4-carboxylic acid ethyl ester

: 71621-30-2
2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;

Reference yield:

: 10606-73-2,99531-04-1,116836-53-4,4773-33-5
ethyl 2-chloro-2-phenylacetate

: 71621-30-2
2-[α-(2-methoxyphenoxy)-benzyl]-4-methyl-morpholine hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaH / 1.) dimethylacetamide, 1-1.5 h, 40 deg C; 2.) dimethylacetamide, 5 h, 90 deg C

2: KOH / methanol / 20 h / Ambient temperature

3: SOCl₂ / 16 h / Ambient temperature

4: LiAlH(O-tBu)3 / bis-(2-methoxy-ethyl) ether / 0.5 h / -60 °C

5: 1.) Na₂S₂O₅; 2.) KCN / 1.) H₂O, EtOH, 16 h, 55 deg C; 2.) H₂O, EtOH, 7 h, reflux

6: LiAlH₄ / diethyl ether; tetrahydrofuran / also with BH₃; 1.) 16 h, RT; 2.) 1 h, 40 deg C

7: Et₃N / CH₂Cl₂ / 0.5 h / -5 °C

8: t-BuOK / 2-methyl-propan-2-ol / 1 h / Ambient temperature

9: sodium bis(2-methoxy-ethoxy)aluminium hydride / toluene / 20 h / Ambient temperature

10: NaOH / CHCl₃

11: 58 percent / LiAlH₄ / diethyl ether

With potassium cyanide; sodium metabisulfite; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydride; lithium tri-t-butoxyaluminum hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; diethylene glycol dimethyl ether; toluene; tert-butyl alcohol;