4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Base Information

Chemical Name:4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one
CAS No.:890414-33-2
Molecular Formula:C₂₇H₃₃NO₂S₂
Molecular Weight:467.697
Hs Code.:

Synonyms:4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Suppliers and Price of 4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

There total 12 articles about 4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 890414-31-0
(3E)-4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]but-3-en-2-one

: 890414-33-2
4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Guidance literature:: With sodium dithionate; sodium hydrogencarbonate; In 1,4-dioxane; water; at 50 ℃; for 1h;
DOI:10.1007/s00044-005-0126-y

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 890414-33-2
4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 75 percent / DIBAL-H / Pd(PPh₃)2Cl₂ / tetrahydrofuran / 2 h / 0 °C

2: 72 percent / CuBr₂ / ethyl acetate; CHCl₃ / 1 h / 55 °C

3: 95 percent / acetone / 12 h / Heating

4: 71 percent / p-toluene sulfonylhydrazide; sodium acetate trihydrate / tetrahydrofuran; H₂O / 5 h / Heating

5: 65 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

6: 90 percent / imidazole / CH₂Cl₂ / 5 h / 20 °C

7: 73 percent / t-BuONO; CuBr₂ / acetonitrile / 2 h / 80 °C

8: 85 percent / n-BuLi / diethyl ether; hexane / -78 - -40 °C

9: 89 percent / benzene / 1 h / Heating

10: 58 percent / p-TsOH / tetrahydrofuran; H₂O / 12 h / 20 °C

11: 60 percent / NaHCO₃; sodium dithionate / dioxane; H₂O / 1 h / 50 °C

With 1H-imidazole; sodium dithionate; lithium aluminium tetrahydride; n-butyllithium; tert.-butylnitrite; sodium acetate; diisobutylaluminium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; toluene-4-sulfonic acid hydrazide; copper(ll) bromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; chloroform; water; ethyl acetate; acetone; acetonitrile; benzene; 1: Reformatsky reaction / 3: Hantzsch reaction / 7: Sandmeyer reaction / 9: Wittig olefination;
DOI:10.1007/s00044-005-0126-y

Reference yield:

: 890414-10-5
ethyl (6E)-5-oxo-7-phenylhept-6-enoate

: 890414-33-2
4-[5-(3-hydroxypropyl)-4-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 72 percent / CuBr₂ / ethyl acetate; CHCl₃ / 1 h / 55 °C

2: 95 percent / acetone / 12 h / Heating

3: 71 percent / p-toluene sulfonylhydrazide; sodium acetate trihydrate / tetrahydrofuran; H₂O / 5 h / Heating

4: 65 percent / LiAlH₄ / diethyl ether / 2 h / 20 °C

5: 90 percent / imidazole / CH₂Cl₂ / 5 h / 20 °C

6: 73 percent / t-BuONO; CuBr₂ / acetonitrile / 2 h / 80 °C

7: 85 percent / n-BuLi / diethyl ether; hexane / -78 - -40 °C

8: 89 percent / benzene / 1 h / Heating

9: 58 percent / p-TsOH / tetrahydrofuran; H₂O / 12 h / 20 °C

10: 60 percent / NaHCO₃; sodium dithionate / dioxane; H₂O / 1 h / 50 °C

With 1H-imidazole; sodium dithionate; lithium aluminium tetrahydride; n-butyllithium; tert.-butylnitrite; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; toluene-4-sulfonic acid hydrazide; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; dichloromethane; chloroform; water; ethyl acetate; acetone; acetonitrile; benzene; 2: Hantzsch reaction / 6: Sandmeyer reaction / 8: Wittig olefination;
DOI:10.1007/s00044-005-0126-y