(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

Base Information

Chemical Name:(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane
CAS No.:113133-26-9
Molecular Formula:C₂₀H₂₉NO₃
Molecular Weight:331.455
Hs Code.:

Synonyms:(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

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Chemical Property of (+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

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Technology Process of (+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

There total 6 articles about (+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 113133-25-8
(+)-(3S,4R)-3-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-4-phenylcyclohex-1-ene

: 113133-26-9
(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

Guidance literature:: With hydrogen; platinum on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00246a012

Reference yield:

: 14002-52-9
o-phenylbenzoyl chloride

: 113133-26-9
(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 2 h / -20 °C

2: 92 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / Ambient temperature

3: K, NH₃, t-BuOH / tetrahydrofuran / 0.75 h / -78 °C

4: 88 percent / H₂ / Pt/C / ethyl acetate

With ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; platinum on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jo00246a012

Reference yield:

: 113133-13-4
1-<<2(S)-(hydroxymethyl)pyrrolidinyl>carbonyl>-2-phenylbenzene

: 113133-26-9
(+)-(1S,2R)-1-<<2(S)-<(methoxymethoxy)methyl>pyrrolidinyl>carbonyl>-2-phenylcyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / diisopropylethylamine / CH₂Cl₂ / 12 h / Ambient temperature

2: K, NH₃, t-BuOH / tetrahydrofuran / 0.75 h / -78 °C

3: 88 percent / H₂ / Pt/C / ethyl acetate

With ammonia; hydrogen; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; platinum on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jo00246a012