methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

Base Information

Chemical Name:methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate
CAS No.:1420459-41-1
Molecular Formula:C₂₈H₄₄N₂O₄Sn
Molecular Weight:591.378
Hs Code.:

Synonyms:methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

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Chemical Property of methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

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Technology Process of methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

There total 1 articles about methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1420459-25-1
methyl 2-(4-iodobenzyl)-3-oxo-4,5,7,8-tetrahydro-2H-isoxazolo[4,5-d]azepine-6(3H)-carboxylate

: 813-19-4
bis(tri-n-butyltin)

: 1420459-41-1
methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 22h; Reflux; Inert atmosphere;
DOI:10.1021/jm301656h

Reference yield: 71.0%

: 1420459-41-1
methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

: 1420459-25-1
methyl 2-(4-iodobenzyl)-3-oxo-4,5,7,8-tetrahydro-2H-isoxazolo[4,5-d]azepine-6(3H)-carboxylate

Guidance literature:: With chloramine T trihydrate; sodium iodide; In aq. phosphate buffer; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;
DOI:10.1021/jm301656h

Reference yield:

: 1420459-41-1
methyl 2-(tributylstannylbenzyl)-3-oxo-4,5,7,8-tetrahydro-2Hisoxazolo[4,5-d]azepine-6(3H)-carboxylate

: 1420459-27-3
C₁₄H₁₅IN₂O₂*BrH

Guidance literature:: Multi-step reaction with 2 steps

1: chloramine T trihydrate; sodium iodide / ethyl acetate; acetic acid; water; N,N-dimethyl-formamide; aq. phosphate buffer / 0.42 h / 20 °C

2: hydrogen bromide / acetic acid / 20 h / 110 °C

With hydrogen bromide; chloramine T trihydrate; sodium iodide; In aq. phosphate buffer; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm301656h