((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester
CAS No.:199340-38-0
Molecular Formula:C₂₇H₄₁N₅O₃
Molecular Weight:483.654
Hs Code.:

Synonyms:((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

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Chemical Property of ((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

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Technology Process of ((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

There total 1 articles about ((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 71-44-3
Spermine

: 2578-84-9
N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester

: 199340-38-0
((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

Guidance literature:: In tetrahydrofuran; for 6h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00137-5

Reference yield: 67.0%

: 30189-36-7
N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester

: 199340-38-0
((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

: 199340-40-4
[(S)-5-(3-{4-[3-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-propylamino]-butylamino}-propylcarbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; for 5h; Ambient temperature;
DOI:10.1016/S0968-0896(97)00137-5

Reference yield:

: 199340-38-0
((S)-1-{3-[4-(3-Amino-propylamino)-butylamino]-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

: (S)-2,6-Diamino-hexanoic acid [3-(4-{3-[(S)-2-(6-amino-hexanoylamino)-3-phenyl-propionylamino]-propylamino}-butylamino)-propyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 67 percent / Et₃N / tetrahydrofuran / 5 h / Ambient temperature

2: 100 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 88 percent / H₂ / 10percent Pd/C / methanol / 4 h

4: 88 percent / EDC, DMAP / CH₂Cl₂ / 5 h / Ambient temperature

5: 87 percent / H₂ / 10percent Pd/C / methanol / 4 h

6: 100 percent / TFA / CH₂Cl₂ / 12 h / Ambient temperature

With dmap; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00137-5