(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

Base Information

Chemical Name:(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione
CAS No.:1374824-26-6
Molecular Formula:C₂₁H₂₉NO₆
Molecular Weight:391.464
Hs Code.:

Synonyms:(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

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Technology Process of (S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

There total 3 articles about (S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 3709-38-4
2,2-dimethyl-5-phenethyl-[1,3]dioxane-4,6-dione

: 1374824-09-5
2-nitro-5-methylhex-1-ene

: 1374824-26-6
(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

Guidance literature:: With (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide; In cyclopentyl methyl ether; at -30 ℃; optical yield given as %ee; enantioselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/ja3026196 DOI:10.1021/ja306016b

Reference yield:

: 14424-33-0
1-nitro-2-methylpentane

: 1374824-26-6
(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / ethanol; water / 1.33 h / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 °C / Inert atmosphere

1.3: 0 °C / Inert atmosphere

2.1: phthalic anhydride / 150 - 180 °C / vacuum

3.1: (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide / cyclopentyl methyl ether / -30 °C / Molecular sieve; Inert atmosphere

With phthalic anhydride; (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide; sodium hydroxide; In ethanol; cyclopentyl methyl ether; water;
DOI:10.1021/ja3026196

Reference yield:

: C₇H₁₅NO₃

: 1374824-26-6
(S)-2,2-dimethyl-5-(2-nitro-5-methylhexyl)-5-phenethyl-1,3-dioxane-4,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: phthalic anhydride / 150 - 180 °C / vacuum

2: (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide / cyclopentyl methyl ether / -30 °C / Molecular sieve; Inert atmosphere

With phthalic anhydride; (R)-2,4,6-triisopropyl-N-((2-methyl-2-morpholinopropyl)carbamoyl)benzenesulfinamide; In cyclopentyl methyl ether;
DOI:10.1021/ja3026196 DOI:10.1021/ja306016b