N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

Base Information

Chemical Name:N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide
CAS No.:59469-64-6
Molecular Formula:C₂₀H₁₆ClFN₄O
Molecular Weight:382.825
Hs Code.:

<i>N</i>-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4<i>H</i>-benzo[<i>f</i>]imidazo[1,5-<i>a</i>][1,4]diazepin-3-yl]-acetamide

Synonyms:N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

Chemical Property:

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Technology Process of N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

There total 4 articles about N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59468-80-3
[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-carbamic acid benzyl ester

: 59469-64-6
N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

Guidance literature:: With acetic anhydride; palladium on charcoal; In ethanol; dichloromethane; acetic acid; ethyl acetate;

Reference yield:

: 59468-44-9
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid

: 59469-64-6
N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; benzyl alcohol / N-methyl-acetamide; toluene

2: acetic anhydride / palladium on charcoal / ethanol; dichloromethane; acetic acid; ethyl acetate

With acetic anhydride; triethylamine; benzyl alcohol; palladium on charcoal; In N-methyl-acetamide; ethanol; dichloromethane; acetic acid; ethyl acetate; toluene;

Reference yield:

: 59468-42-7
8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylic acid methyl ester

: 59469-64-6
N-[8-chloro-6-(2-fluoro-phenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol; water

2: triethylamine; benzyl alcohol / N-methyl-acetamide; toluene

3: acetic anhydride / palladium on charcoal / ethanol; dichloromethane; acetic acid; ethyl acetate

With potassium hydroxide; acetic anhydride; triethylamine; benzyl alcohol; palladium on charcoal; In N-methyl-acetamide; methanol; ethanol; dichloromethane; water; acetic acid; ethyl acetate; toluene;