2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

Base Information

Chemical Name:2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester
CAS No.:1027184-12-8
Molecular Formula:C₂₁H₂₂N₂O₃S₂
Molecular Weight:414.549
Hs Code.:

Synonyms:2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

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Chemical Property of 2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

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Technology Process of 2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

There total 4 articles about 2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 2-(hydroxyethylidene)-1-pyridin-3-ylcyclohexanecarbodithionic acid methyl ester

: 1027184-12-8
2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 5 ℃; for 0.0833333h;
DOI:10.1021/jm00063a010

Reference yield:

: 124034-66-8
2-(pyridin-3-yl)-cyclohexanone

: 1027184-12-8
2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) t-BuOK

2: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 3 h

3: 53 percent / DIBAL / CH₂Cl₂; toluene / 2 h / -20 - 20 °C

4: 66 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature

5: Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 0.08 h / 0 - 5 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium tert-butylate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00063a010

Reference yield:

: 131332-42-8
2-oxo-1-pyridin-3-ylcyclohexanecarbodithioic acid methyl ester

: 1027184-12-8
2-[2-(4-Nitro-phenoxy)-eth-(E)-ylidene]-1-pyridin-3-yl-cyclohexanecarbodithioic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 3 h

2: 53 percent / DIBAL / CH₂Cl₂; toluene / 2 h / -20 - 20 °C

3: 66 percent / NaBH₄ / methanol / 0.5 h / Ambient temperature

4: Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 0.08 h / 0 - 5 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm00063a010