N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Base Information

Chemical Name:N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine
CAS No.:203795-48-6
Molecular Formula:C₄₁H₇₂N₁₀O₃
Molecular Weight:753.088
Hs Code.:

N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Synonyms:N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

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Chemical Property of N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

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Technology Process of N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

There total 12 articles about N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1184-90-3
aminoiminomethanesulfonic acid

: 203795-46-4
Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(2-amino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine: 203795-48-6
N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Guidance literature:: In methanol; chloroform; at 20 ℃; for 24h;

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine: 203795-48-6
N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

4: NaBH₄

5: 78 percent / Et₃N / CH₂Cl₂

6: 66 percent / NaN₃ / dimethylsulfoxide

7: 94 percent / TsOH / methanol

8: 99 percent / Et₃N / CH₂Cl₂

9: 95 percent

10: 95 percent / LiAlH₄ / tetrahydrofuran

11: 91 percent / methanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; dimethylsulfide; sodium hydride; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r

Reference yield:

: 1448-36-8
methyl cholate

N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine: 203795-48-6
N-{2-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(2-guanidino-ethoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-ethyl}-guanidine

Guidance literature:: Multi-step reaction with 12 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) O₃, 2.) Me₂S / 1.) CH₂Cl₂, MeOH

5: NaBH₄

6: 78 percent / Et₃N / CH₂Cl₂

7: 66 percent / NaN₃ / dimethylsulfoxide

8: 94 percent / TsOH / methanol

9: 99 percent / Et₃N / CH₂Cl₂

10: 95 percent

11: 95 percent / LiAlH₄ / tetrahydrofuran

12: 91 percent / methanol

With sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; dimethylsulfide; sodium hydride; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r