(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Base Information

Chemical Name:(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine
CAS No.:139277-14-8
Molecular Formula:C₂₁H₂₂O₅S
Molecular Weight:386.469
Hs Code.:

Synonyms:(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Suppliers and Price of (4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

There total 7 articles about (4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109-87-5
Dimethoxymethane

: 139277-13-7
(1S,2R,6S)-3-Benzenesulfonyl-2-benzyloxy-6-benzyloxymethyl-cyclohex-3-enol

: 139277-14-8
(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 36h; Heating;
DOI:10.1021/jo00033a002

Reference yield:

: 24363-23-3,38263-45-5,38263-46-6,64589-22-6,90760-55-7,90760-56-8,117772-64-2
(+/-)-7-oxabicyclo[2.2.1]hept-5-ene-2-endo-carboxylic acid

: 139277-14-8
(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / CHCl₃ / 48 h / 0 deg C to r.t.

2: 90 percent / LAH / tetrahydrofuran / 1 h / 0 °C

3: 90 percent / KOH / dioxane / 3 h / Heating

4: 97 percent / magnesium monoperoxyphthalate (MMPP) / methanol / 0 °C

5: 90 percent / n-BuLi, TMEDA / toluene; CH₂Cl₂ / 0.25 h / -78 °C

6: 88 percent / p-TsOH, 3A MS / CH₂Cl₂ / 36 h / Heating

With potassium hydroxide; lithium aluminium tetrahydride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; toluene;
DOI:10.1021/jo00033a002

Reference yield:

: 139277-09-1
(1R,2S,3R,4S,6R)-6-Hydroxymethyl-3-phenylsulfanyl-7-oxa-bicyclo[2.2.1]heptan-2-ol

: 139277-14-8
(4aS,8R,8aS)-7-Benzenesulfonyl-8-benzyloxy-4a,5,8,8a-tetrahydro-4H-benzo[1,3]dioxine

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / KOH / dioxane / 3 h / Heating

2: 97 percent / magnesium monoperoxyphthalate (MMPP) / methanol / 0 °C

3: 90 percent / n-BuLi, TMEDA / toluene; CH₂Cl₂ / 0.25 h / -78 °C

4: 88 percent / p-TsOH, 3A MS / CH₂Cl₂ / 36 h / Heating

With potassium hydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; toluene-4-sulfonic acid; magnesium monoperoxyphthalate hexahydrate; In 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1021/jo00033a002