N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

Base Information

Chemical Name:N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine
CAS No.:181115-88-8
Molecular Formula:C₂₄H₂₂ClFN₂
Molecular Weight:392.903
Hs Code.:

Synonyms:N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

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Chemical Property of N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

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Technology Process of N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

There total 4 articles about N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: Benzyl-[2-(6-chloro-1H-indol-3-yl)-ethyl]-methyl-amine

: 181115-88-8
N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

Guidance literature:: With potassium carbonate; In various solvent(s); at 165 ℃; for 8h;
DOI:10.1021/jm960159f

Reference yield:

: 17422-32-1
5-chloro-1H-indole

: 181115-88-8
N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

Guidance literature:: Multi-step reaction with 4 steps

1: diethyl ether / 0.5 h / 0 - 5 °C

2: Et₃N / diethyl ether / 0 - 5 °C

3: LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

4: K₂CO₃ / various solvent(s) / 8 h / 165 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm960159f

Reference yield:

: 883-55-6
2-(5-chloro-1H-indol-3-yl)-2-oxoacetyl chloride

: 181115-88-8
N-benzyl-N-methyl-2-[6-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]ethylamine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / diethyl ether / 0 - 5 °C

2: LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

3: K₂CO₃ / various solvent(s) / 8 h / 165 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether;
DOI:10.1021/jm960159f