O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine

Base Information

• Chemical Name: O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine
• CAS No.: 1235478-82-6
• Molecular Formula: C₃₉H₄₂N₂O₇
• Molecular Weight: 650.772

Synonyms:O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine

Chemical Property of O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine

Chemical Property:

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Technology Process of O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine

There total 4 articles about O⁴-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H24N2O5 + 4,4'-dimethoxytrityl chloride (40615-36-9) → O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6) + O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

DOI:10.1021/ja102871p

Reference yield:

C18H24N2O5 + 4,4'-dimethoxytrityl chloride (40615-36-9) → O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6) + O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6)

Guidance literature:

With pyridine; dmap; at 0 - 20 ℃;

DOI:10.1021/ja102871p

Reference yield:

3',5'-diacetyl-O4-bicyclo[2.2.1]hept-5-en-2-ylmethylthymidine (1235478-80-4) → O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6) + O4-(bicyclo[2.2.1]hept-5-en-2-ylmethyl)-5'-O-(4,4'-dimethoxytrityl)-2'-desoxythymidine (1235478-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / water; methanol / 2.5 h / 20 °C

2: dmap; pyridine / 18 h / 0 - 20 °C

With pyridine; dmap; ammonia; In methanol; water;

upstream raw materials:

4,4'-dimethoxytrityl chloride

3',5'-diacetyl-O⁴-bicyclo[2.2.1]hept-5-en-2-ylmethylthymidine

Downstream raw materials:

C₄₈H₅₉N₄O₈P

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