(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

Base Information

Chemical Name:(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one
CAS No.:1027340-32-4
Molecular Formula:C₁₆H₂₁NOSi
Molecular Weight:271.434
Hs Code.:

Synonyms:(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

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Chemical Property of (5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

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Technology Process of (5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

There total 4 articles about (5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₅NO₂S₂Si

: 1027340-32-4
(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

Guidance literature:: for 4h; Inert atmosphere; Reflux;
DOI:10.1016/j.tetasy.2014.12.002

Reference yield:

: 1027340-30-2
(5S,7R,7aR)-5-((dimethyl(phenyl)silyl)methyl)-7-((S)-1-(2,4,6-triisopropylphenyl)ethoxy)-hexahydro-1H-pyrrolizin-3-one

: 1027340-32-4
(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: potassium hydride / tetrahydrofuran / 1 h / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

2.3: 12 h / 0 - 20 °C / Inert atmosphere

3.1: 4 h / Inert atmosphere; Reflux

With potassium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2014.12.002

Reference yield:

: 1027340-31-3
(5S,7R,7aR)-5-((dimethyl(phenyl)silyl)methyl)-7-hydroxy-hexahydro-1H-pyrrolizin-3-one

: 1027340-32-4
(5S,7aR)-5-((dimethyl(phenyl)silyl)methyl)-1,2,5,7a-tetrahydropyrrolizin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydride / tetrahydrofuran / 1 h / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

1.3: 12 h / 0 - 20 °C / Inert atmosphere

2.1: 4 h / Inert atmosphere; Reflux

With potassium hydride; In tetrahydrofuran;
DOI:10.1016/j.tetasy.2014.12.002