(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

Base Information

Chemical Name:(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide
CAS No.:1348622-25-2
Molecular Formula:C₂₃H₂₆N₆O
Molecular Weight:402.499
Hs Code.:

Synonyms:(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

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Chemical Property of (E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

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Technology Process of (E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

There total 6 articles about (E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 774534-34-8
4-(N,N-dimethylamino)-2-ene-butyryl chloride

: 1202759-56-5
C₁₇H₁₇N₅

: 1348622-25-2
(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

Guidance literature:: 4-(N,N-dimethylamino)-2-ene-butyryl chloride; C₁₇H₁₇N₅; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 1h;

With triethylamine; In 1-methyl-pyrrolidin-2-one; water;

Reference yield:

: 98548-82-4
4-(dimethylamino)but-2-enoic acid

: 1348622-25-2
(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride / acetonitrile / 2.58 h / 0 - 45 °C

2: 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

With oxalyl dichloride; In 1-methyl-pyrrolidin-2-one; acetonitrile;

Reference yield:

: 1780-31-0
2,6-dichloro-5-methylpyrimidine

: 1348622-25-2
(E)-4-(dimethylamino)-N-(3-(5-methyl-2-(phenylamino)pyrimidin-4-ylamino)phenyl)but-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 0.5 h / 120 °C / Microwave irradiation

2: 1-methyl-pyrrolidin-2-one / 0.17 h / 200 °C / Microwave irradiation

3: 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; butan-1-ol;