H-LYS-AMC ACOH

Base Information

• Chemical Name: H-LYS-AMC ACOH
• CAS No.: 92605-76-0
• Molecular Formula: C₁₆H₂₁N₃O₃
• Molecular Weight: 303.361
• Mol file: 92605-76-0.mol

Synonyms:Hexanamide,2,6-diamino-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-, (S)-; L-Lysine4-methylcoumaryl-7-amide

Chemical Property of H-LYS-AMC ACOH

Chemical Property:

• Boiling Point: 573.9±50.0 °C (760 mmHg)
• PSA: 111.35000
• Density: 1.253±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.96980

Purity/Quality:

99% ^*data from raw suppliers

(S)-2,6-Diamino-N-(4-methyl-2-oxo-2H-chromen-7-yl)hexanamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-LYS-AMC ACOH

There total 4 articles about H-LYS-AMC ACOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

tert-butyl (S)-(5-amino-6-((4-methyl-2-oxo-2H-chromen-7-yl)-amino)-6-oxohexyl) carbamate (222037-62-9) → Lys-4-methylcoumaryl-7-amide (92605-76-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.3390/molecules26020482

Reference yield:

7-amino-4-methylcoumarin. (26093-31-2) → Lys-4-methylcoumaryl-7-amide (92605-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With piperidine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules26020482

Reference yield:

Fmoc-Lys(tert-butoxycarbonyl) (71989-26-9) → Lys-4-methylcoumaryl-7-amide (92605-76-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 1 h / 0 °C

1.2: 20 °C

2.1: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With piperidine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules26020482

upstream raw materials:

7-amino-4-methylcoumarin.

Fmoc-Lys(tert-butoxycarbonyl)

(9H-fluoren-9-yl)methyl-tert-butyl (6-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-6-oxohexane-1,5-diyl)-(S)-dicarbamate

tert-butyl (S)-(5-amino-6-((4-methyl-2-oxo-2H-chromen-7-yl)-amino)-6-oxohexyl) carbamate